Colchicine Versus Prednisone as Treatment of Usual Interstitial Pneumonia
Identifieur interne : 000255 ( an2020/Analysis ); précédent : 000254; suivant : 000256Colchicine Versus Prednisone as Treatment of Usual Interstitial Pneumonia
Auteurs : William W. Douglas [États-Unis] ; Jay H. Ryu [États-Unis] ; Julie A. Bjoraker [États-Unis] ; Darrell R. Schroeder [États-Unis] ; Jeffrey L. Myers [États-Unis] ; Henry D. Tazelaar [États-Unis] ; Stephen J. Swensen [États-Unis] ; Paul D. Scanlon [États-Unis] ; Steve G. Peters [États-Unis] ; Richard A. Deremee [États-Unis]Source :
- Mayo Clinic Proceedings [ 0025-6196 ] ; 1997.
English descriptors
- Teeft :
- Absolute change, Adverse reactions, Alveolitis, American thoracic society, Arthritis rheum, Baseline, Better prognosis, Bibasilar inspiratory, Biopsy, Biopsy specimens, Carbon monoxide, Chronic hypersensitivity pneumonia, Chronic hypersensitivity pneumonitis, Clin, Clinic, Clinical information, Colchicine, Colchicine group, Colchicine registry, Colchicine therapy, Colchicine treatment, Colchicinetreated patients, Corresponding numbers, Creatinine levels, Critical care medicine, Cryptogenic fibrosing alveolitis, Current study, Discrete variables, Dlco, Drug therapy, Drug treatment, Entire registry, Failure curves, Familial mediterranean fever, Fibrosing, Fibrosing alveolitis, Fibrosis, Further support, Hrct, Hypersensitivity pneumonitis, Idiopathic, Initial therapy, Intolerable diarrhea, Leukocytoclastic vasculitis, Linear regression model, Lung disease, Lung volumes, Mayo, Mayo clin proc, Mayo clinic jacksonville, Mayo clinic proceedings, Mayo clinic rochester, Mayo clinic scottsdale, Mayo clio proc, Mild diarrhea, Monoxide, Ncip, Other drugs, Oxygen saturation, Pfts, Pneumonia, Prediction equations, Prednisone, Prednisone colchicine, Prednisone group, Prednisone therapy, Prednisone treatment, Prednisonetreated patients, Primary biliary cirrhosis, Proc, Progressive dyspnea, Proximal muscle weakness, Pulmonary fibrosis, Pulmonary function, Pulmonary function tests, Radiology, Recurrent pericarditis, Regression line, Renal function, Respir, Reticular opacities, Second drug, Serious side effects, Side effects, Significant decline, Significant difference, Significant differences, Solid line, Special interest, Study group, Therapy, Total lung capacity, Transfer factor, Treatment groups, Treatment regimen, Unknown cause, Vital capacity.
Abstract
Objective To assess the results with colchicine and prednisone as initial single-drug therapy in patients with usual interstitial pneumonia (UIP).Material and Methods We reviewed the serial pulmonary function test results in 22 patients with typical clinical and high-resolution computed tomographic features of UIP who were treated with colchicine as initial single-agent therapy and compared them with a group of 22 historical patients with UIP of similar severity diagnosed by open-lung biopsy who were given prednisone as initial single-drug therapy.Results No significant difference was detected in the rate of decline of pulmonary function or in the time to failure between the two study groups. A trend was suggested for more rapid decline of pulmonary function in the prednisone-treated than in the colchicine-treated group. The design of this study does not allow distinction between a possible beneficial effect of colchicine and a possible adverse effect related to weaning from high-dose prednisone. Colchicine was well tolerated; few side effects other than mild diarrhea were noted in those patients able to take the drug long enough to return for pulmonary function testing at 3 months. In comparison, the side effects of prednisone were more serious and were not always reversible with cessation of therapy.Conclusion This study lends further support to the assumption that colchicine may be a satisfactory and less hazardous substitute for prednisone in the treatment of patients with UIP.
Url:
DOI: 10.4065/72.3.201
Affiliations:
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<term>Adverse reactions</term>
<term>Alveolitis</term>
<term>American thoracic society</term>
<term>Arthritis rheum</term>
<term>Baseline</term>
<term>Better prognosis</term>
<term>Bibasilar inspiratory</term>
<term>Biopsy</term>
<term>Biopsy specimens</term>
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<term>Chronic hypersensitivity pneumonia</term>
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<term>Clinic</term>
<term>Clinical information</term>
<term>Colchicine</term>
<term>Colchicine group</term>
<term>Colchicine registry</term>
<term>Colchicine therapy</term>
<term>Colchicine treatment</term>
<term>Colchicinetreated patients</term>
<term>Corresponding numbers</term>
<term>Creatinine levels</term>
<term>Critical care medicine</term>
<term>Cryptogenic fibrosing alveolitis</term>
<term>Current study</term>
<term>Discrete variables</term>
<term>Dlco</term>
<term>Drug therapy</term>
<term>Drug treatment</term>
<term>Entire registry</term>
<term>Failure curves</term>
<term>Familial mediterranean fever</term>
<term>Fibrosing</term>
<term>Fibrosing alveolitis</term>
<term>Fibrosis</term>
<term>Further support</term>
<term>Hrct</term>
<term>Hypersensitivity pneumonitis</term>
<term>Idiopathic</term>
<term>Initial therapy</term>
<term>Intolerable diarrhea</term>
<term>Leukocytoclastic vasculitis</term>
<term>Linear regression model</term>
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<term>Lung volumes</term>
<term>Mayo</term>
<term>Mayo clin proc</term>
<term>Mayo clinic jacksonville</term>
<term>Mayo clinic proceedings</term>
<term>Mayo clinic rochester</term>
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<term>Ncip</term>
<term>Other drugs</term>
<term>Oxygen saturation</term>
<term>Pfts</term>
<term>Pneumonia</term>
<term>Prediction equations</term>
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<term>Prednisone colchicine</term>
<term>Prednisone group</term>
<term>Prednisone therapy</term>
<term>Prednisone treatment</term>
<term>Prednisonetreated patients</term>
<term>Primary biliary cirrhosis</term>
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<term>Progressive dyspnea</term>
<term>Proximal muscle weakness</term>
<term>Pulmonary fibrosis</term>
<term>Pulmonary function</term>
<term>Pulmonary function tests</term>
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<term>Recurrent pericarditis</term>
<term>Regression line</term>
<term>Renal function</term>
<term>Respir</term>
<term>Reticular opacities</term>
<term>Second drug</term>
<term>Serious side effects</term>
<term>Side effects</term>
<term>Significant decline</term>
<term>Significant difference</term>
<term>Significant differences</term>
<term>Solid line</term>
<term>Special interest</term>
<term>Study group</term>
<term>Therapy</term>
<term>Total lung capacity</term>
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<front><div type="abstract">Objective To assess the results with colchicine and prednisone as initial single-drug therapy in patients with usual interstitial pneumonia (UIP).Material and Methods We reviewed the serial pulmonary function test results in 22 patients with typical clinical and high-resolution computed tomographic features of UIP who were treated with colchicine as initial single-agent therapy and compared them with a group of 22 historical patients with UIP of similar severity diagnosed by open-lung biopsy who were given prednisone as initial single-drug therapy.Results No significant difference was detected in the rate of decline of pulmonary function or in the time to failure between the two study groups. A trend was suggested for more rapid decline of pulmonary function in the prednisone-treated than in the colchicine-treated group. The design of this study does not allow distinction between a possible beneficial effect of colchicine and a possible adverse effect related to weaning from high-dose prednisone. Colchicine was well tolerated; few side effects other than mild diarrhea were noted in those patients able to take the drug long enough to return for pulmonary function testing at 3 months. In comparison, the side effects of prednisone were more serious and were not always reversible with cessation of therapy.Conclusion This study lends further support to the assumption that colchicine may be a satisfactory and less hazardous substitute for prednisone in the treatment of patients with UIP.</div>
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<name sortKey="Ryu, Jay H" sort="Ryu, Jay H" uniqKey="Ryu J" first="Jay H." last="Ryu">Jay H. Ryu</name>
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